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BIOMYC-1 is a solution based on the antibiotic Tiamutin. BIOMYC-2 is a solution based on the antibiotic Minocycline, which is a member of the Tetracycline group.
These two antibiotics have been shown to be effective in eliminating the mycoplasma species frequently present in contaminated cell cultures. Furthermore, the mycoplasmas do not develop resistance to these antibiotics – a common occurrence with other antibiotic treatment methods.
The treatment is based on alternating use of the two antibiotics:
four days with Tiamutin followed by three days with Minocycline, and repeating the cycle three times.
On completion of the treatment, the cells should be grown on media without antibiotics for at least two weeks and then re-tested for the presence of mycoplasma. If the culture tests positive, the course of treatment should be repeated.
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